![]() ![]() She has published more than 20 papers and has a licensed patent. Skrydstrup, working on sila-amino acids and peptides, she returned to CSIC, where she holds a postdoctoral research contract (Transaludagro project). After a two-year postdoctoral stay at Aarhus University (Denmark) with Prof. One of her research lines is based on the study of the different reactivity of O- and N-radicals, obtained from hypervalent iodine reagents, for the selective modification of carbohydrates and peptides.ĭr Dácil Hernández received her PhD in Chemistry at the University of La Laguna (Spain) in 2007 and was awarded one of the PhD University Prizes for her work on the modification of carbohydrates and amino acids to give nucleoside analogs and alkaloids. Since 2001 she has been a Senior Scientist at IPNA – CSIC. ![]() From 1998–2001, she worked as a post-doctoral fellow at the University of Strathclyde (Glasgow) under the direction of Prof. She carried out her PhD work at IPNA-CSIC, obtaining her PhD in 1997 (University of La Laguna-ULL). Part of the results have been transferred to chemical and agrotech companies, and some are commercialized internationally.ĭr Concepción González graduated in Chemistry from the University of La Laguna. Her 80 publications include several Featured Articles/Covers in the selective modification of peptides. She has also been Coordinator of Scientific Outreach (2007–2019) and Deputy Director of IPNA-CSIC (2013–2020). She has recently participated as an Expert in the preparation of CSIC White Report on the ‘Biomedicine and Health’ Challenges. She works on the development of synthetic methodologies and their application to drug synthesis, particularly antimicrobial and antitumoral agents. In addition to chemical methodologies, the review addresses some reactions, catalyzed by natural or engineered enzymes, that afford unprecedent regio- and stereoselectivity in backbone modifications.ĭr Alicia Boto is Research Scientist at the Spanish Research Council (CSIC) in IPNA-CSIC (Tenerife-Spain). Moreover, not only the modifications in internal backbone positions, but also in the N- and C-termini are discussed. the formation of thioamides or heterocycles, which alters backbone rigidity and ability to form hydrogen bonds or recognition by enzymes, is also described. The site-selective modification of the peptide bond, i.e. This review addresses the selective modification of Cα- and N-positions, from the use of “customizable units” to the residue-directed introduction of substituents. In the last few years, many advances towards this goal have been developed. However, to achieve selectivity in the core of these biopolymers is challenging. The site-selective modification of peptide backbones allows an outstanding fine-tuning of peptide conformation, folding ability, and physico-chemical and biological properties. ![]()
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